Clinical Significance of Langerhans Cells in Squamous Cell Carcinoma of the Larynx
Joint Authors
Redondo, Maximino
Ruiz-Cabello, Francisco
Lopez-Gonzalez, Miguel Angel
Esteban, Francisco
Gonzalez-Moles, Miguel Angel
Funez, Rafael
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Langerhans cells (LCs) may be involved in the immunosurveillance against tumors as antigen-presenting cells.
Our objective has been to determine the relevance of LC in progression of larynx squamous cell carcinomas and their relationship with different subpopulations of tumor-infiltrating cells.
LCs were investigated by immunohistochemical methods using anti-CD1 antibody.
LCs were detected in most of the primary tumors studied (44 out of 50) and also in metastases (6 out of 10) and recurrences (2 out of 3), but we did not find any statistical association between number of LCs and clinical-pathological parameters or survival.
However, the number of LCs was increased in patients with evident infiltration of lymphocytes, mainly cytotoxic T cells.
We can conclude that although LCs did not show clinical utility as prognostic marker, they may play a role in releasing an active immune response in larynx carcinomas, according to their ability to present antigens to sensitized T cells.
American Psychological Association (APA)
Esteban, Francisco& Ruiz-Cabello, Francisco& Gonzalez-Moles, Miguel Angel& Lopez-Gonzalez, Miguel Angel& Funez, Rafael& Redondo, Maximino. 2012. Clinical Significance of Langerhans Cells in Squamous Cell Carcinoma of the Larynx. Journal of Oncology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496041
Modern Language Association (MLA)
Esteban, Francisco…[et al.]. Clinical Significance of Langerhans Cells in Squamous Cell Carcinoma of the Larynx. Journal of Oncology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-496041
American Medical Association (AMA)
Esteban, Francisco& Ruiz-Cabello, Francisco& Gonzalez-Moles, Miguel Angel& Lopez-Gonzalez, Miguel Angel& Funez, Rafael& Redondo, Maximino. Clinical Significance of Langerhans Cells in Squamous Cell Carcinoma of the Larynx. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496041