TNF-α Polymorphisms in Juvenile Idiopathic Arthritis : Which Potential Clinical Implications?
Joint Authors
Chiarelli, Francesco
Lucantoni, M.
Scardapane, A.
Breda, L.
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Whether tumor necrosis factor alpha (TNF-α) gene polymorphisms (SNPs) influence disease susceptibility and treatment of patients with juvenile idiopathic arthritis (JIA) is presently uncertain.
TNF-α is one of the most important cytokine involved in JIA pathogenesis.
Several single nucleotide polymorphisms (SNPs) have been identified within the region of the TNF-α gene but only a very small minority have proven functional consequences and have been associated with susceptibility to JIA.
An association between some TNF-α SNPs and adult rheumatoid arthritis (RA) susceptibility, severity and clinical response to anti-TNF-α treatment has been reported.
The most frenquetly studied TNF-α SNP is located at −308 position, where a substitution of the G allele with the rare A allele has been found.
The presence of the allele −308A is associated to JIA and to a poor prognosis.
Besides, the −308G genotype has been associated with a better response to anti-TNF-α therapy in JIA patients, confirming adult data.
Psoriatic and oligoarticular arthritis are significantly associated to the −238 SNP only in some works.
Studies considering other SNPs are conflicting and inconclusive.
Large scale studies are required to define the contribution of TNF-α gene products to disease pathogenesis and anti-TNF-α therapeutic efficacy in JIA.
American Psychological Association (APA)
Scardapane, A.& Breda, L.& Lucantoni, M.& Chiarelli, Francesco. 2012. TNF-α Polymorphisms in Juvenile Idiopathic Arthritis : Which Potential Clinical Implications?. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-496241
Modern Language Association (MLA)
Scardapane, A.…[et al.]. TNF-α Polymorphisms in Juvenile Idiopathic Arthritis : Which Potential Clinical Implications?. International Journal of Rheumatology No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-496241
American Medical Association (AMA)
Scardapane, A.& Breda, L.& Lucantoni, M.& Chiarelli, Francesco. TNF-α Polymorphisms in Juvenile Idiopathic Arthritis : Which Potential Clinical Implications?. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-496241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496241