Traffic Control of Bacteria-Derived Molecules : A New System of Host-Bacterial Crosstalk

Joint Authors

Kohgo, Yutaka
Fujiya, Mikihiro
Konishi, Hiroaki

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-03-31

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Biology

Abstract EN

Virulent microorganisms, such as pathogenic bacteria and viruses, are recognized by pattern recognition receptors (PRRs), including toll-like receptors (TLRs) and nucleotide-binding oligomerization-domain proteins (NODs), and induce inflammatory responses in mammalian hosts.

Conversely, commensal bacteria and probiotics, which symbiotically confer health benefits on the host organisms, can lodge in the host intestinal tract without inducing intestinal inflammation.

Recent advances in investigations concerning host-microbial interactions have shown that some effector molecules secreted from beneficial bacteria activate cell survival pathways, such as those mediated by p38 MAPK and Akt, and bring health benefits to mammalian hosts.

It is noteworthy that such bacteria-derived molecules are taken into the intestinal epithelia through a transport or endocytosis system, thereafter exhibiting their beneficial effects.

Understanding this traffic control process can aid in the comprehension of host and microbe interactions and may provide new insight to clarify the pathogenesis of intestinal disorders.

This paper highlights the intestinal trafficking systems of bacteria-derived molecules that affect the bacterial functions and modulate epithelial signaling cascades.

The latter mechanism may contribute to the maintenance of intestinal homeostasis by improving the host damage induced by virulence factors and various disease states.

American Psychological Association (APA)

Konishi, Hiroaki& Fujiya, Mikihiro& Kohgo, Yutaka. 2013. Traffic Control of Bacteria-Derived Molecules : A New System of Host-Bacterial Crosstalk. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-496316

Modern Language Association (MLA)

Konishi, Hiroaki…[et al.]. Traffic Control of Bacteria-Derived Molecules : A New System of Host-Bacterial Crosstalk. International Journal of Cell Biology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-496316

American Medical Association (AMA)

Konishi, Hiroaki& Fujiya, Mikihiro& Kohgo, Yutaka. Traffic Control of Bacteria-Derived Molecules : A New System of Host-Bacterial Crosstalk. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-496316

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-496316