Breast Cancer Preoperative Staging : Does Contrast-Enhanced Magnetic Resonance Mammography Modify Surgery?

Abstract EN

Women with newly diagnosed breast cancer may have lesions undetected by conventional imaging.

Recently contrast-enhanced magnetic resonance mammography (CE-MRM) showed higher sensitivity in breast lesions detection.

The present analysis was aimed at evaluating the benefit of preoperative CE-MRM in the surgical planning.

From 2005 to 2009, 525 consecutive women (25–75 years) with breast cancer, newly diagnosed by mammography, ultrasound, and needle-biopsy, underwent CE-MRM.

The median invasive tumour size was 19 mm.

In 144 patients, CE-MRM identified additional lesions.

After secondlook, 119 patients underwent additional biopsy.

CE-MRM altered surgery in 118 patients: 57 received double lumpectomy or wider excision (41 beneficial), 41 required mastectomy (40 beneficial), and 20 underwent contra lateral surgery (18 beneficial).

The overall false-positive rate was 27.1% (39/144).

CE-MRM contributed significantly to the management of breast cancer, suggesting more extensive disease in 144/525 (27.4%) patients and changing the surgical plan in 118/525 (22.5%) patients (99/525, 18.8% beneficial).