The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease
Joint Authors
Karalliedde, Janaka
Maltese, Giuseppe
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Ageing is a multifactorial process often characterized by a progressive decline in physiological function(s).
Ageing can and is often associated with an increased incidence of cardiovascular and renal disease.
Klotho is a novel antiageing gene that encodes a protein with multiple pleiotropic functions including an emerging role in cardiorenal disease.
Mice deficient for this gene display a phenotype of premature human ageing characterized by diffuse vascular calcification, altered calcium/phosphate metabolism, and shortened lifespan.
Klotho is mainly expressed in the renal tubules but it also exists as circulating soluble form detectable in the blood, with systemic effects.
Reduction in soluble Klotho has been associated with renal disease, hyperphosphataemia, increased oxidative stress, endothelial dysfunction, and diffuse vascular calcification.
Conversely, overexpression of Klotho promotes cardiovascular-renal protection.
The majority of the research on Klotho has been conducted in vitro and in animal studies but there is emerging data from human studies which suggest that Klotho may be a modifiable factor involved in the pathogenesis of cardiovascular and renal disease in at-risk populations.
Further data is required to confirm if this novel protein can emerge as therapeutic tool that may be used to prevent or slow progression of cardiorenal disease.
American Psychological Association (APA)
Maltese, Giuseppe& Karalliedde, Janaka. 2011. The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496349
Modern Language Association (MLA)
Maltese, Giuseppe& Karalliedde, Janaka. The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease. International Journal of Hypertension No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-496349
American Medical Association (AMA)
Maltese, Giuseppe& Karalliedde, Janaka. The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease. International Journal of Hypertension. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496349