Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis : New Perspectives in Neurodegeneration
Joint Authors
Lettieri Barbato, Daniele
Baldelli, Sara
Ciriolo, Maria Rosa
Pagliei, Beatrice
Aquilano, Katia
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mitochondrial activity progressively declines during ageing and in many neurodegenerative diseases.
Caloric restriction (CR) has been suggested as a dietary intervention that is able to postpone the detrimental aspects of aging as it ameliorates mitochondrial performance.
This effect is partially due to increased mitochondrial biogenesis.
The nutrient-sensing PGC-1α is a transcriptional coactivator that promotes the expression of mitochondrial genes and is induced by CR.
It is believed that many of the mitochondrial and metabolic benefits of CR are due to increased PGC-1α activity.
The increase of PGC-1α is also positively linked to neuroprotection and its decrement has been involved in the pathogenesis of many neurodegenerative diseases.
This paper aims to summarize the current knowledge about the role of PGC-1α in neuronal homeostasis and the beneficial effects of CR on mitochondrial biogenesis and function.
We also discuss how PGC-1α-governed pathways could be used as target for nutritional intervention to prevent neurodegeneration.
American Psychological Association (APA)
Lettieri Barbato, Daniele& Baldelli, Sara& Pagliei, Beatrice& Aquilano, Katia& Ciriolo, Maria Rosa. 2012. Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis : New Perspectives in Neurodegeneration. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-496535
Modern Language Association (MLA)
Lettieri Barbato, Daniele…[et al.]. Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis : New Perspectives in Neurodegeneration. International Journal of Cell Biology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-496535
American Medical Association (AMA)
Lettieri Barbato, Daniele& Baldelli, Sara& Pagliei, Beatrice& Aquilano, Katia& Ciriolo, Maria Rosa. Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis : New Perspectives in Neurodegeneration. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-496535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496535