Combined Analysis of CSF Tau, Aβ42, Aβ1–42% and Aβ1–40ox% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia
Joint Authors
Mollenhauer, Brit
Kornhuber, Johannes
Trenkwalder, Claudia
Bibl, Mirko
Lewczuk, Piotr
Esselmann, Hermann
Wiltfang, Jens G.
Otto, Markus
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We studied the diagnostic value of CSF Aβ42/tau versus low Aβ1–42% and high Aβ1–40ox% levels for differential diagnosis of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), respectively.
CSF of 45 patients with AD, 15 with DLB, 21 with Parkinson's disease dementia (PDD), and 40 nondemented disease controls (NDC) was analyzed by Aβ-SDS-PAGE/immunoblot and ELISAs (Aβ42 and tau).
Aβ42/tau lacked specificity in discriminating AD from DLB and PDD.
Best discriminating biomarkers were Aβ1–42% and Aβ1–40ox% for AD and DLB, respectively.
AD and DLB could be differentiated by both Aβ1–42% and Aβ1–40ox% with an accuracy of 80% at minimum.
Thus, we consider Aβ1–42% and Aβ1–40ox% to be useful biomarkers for AD and DLB, respectively.
We propose further studies on the integration of Aβ1–42% and Aβ1–40ox% into conventional assay formats.
Moreover, future studies should investigate the combination of Aβ1–40ox% and CSF alpha-synuclein for the diagnosis of DLB.
American Psychological Association (APA)
Bibl, Mirko& Esselmann, Hermann& Lewczuk, Piotr& Trenkwalder, Claudia& Otto, Markus& Kornhuber, Johannes…[et al.]. 2010. Combined Analysis of CSF Tau, Aβ42, Aβ1–42% and Aβ1–40ox% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-496713
Modern Language Association (MLA)
Bibl, Mirko…[et al.]. Combined Analysis of CSF Tau, Aβ42, Aβ1–42% and Aβ1–40ox% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-496713
American Medical Association (AMA)
Bibl, Mirko& Esselmann, Hermann& Lewczuk, Piotr& Trenkwalder, Claudia& Otto, Markus& Kornhuber, Johannes…[et al.]. Combined Analysis of CSF Tau, Aβ42, Aβ1–42% and Aβ1–40ox% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-496713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496713