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KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats
Joint Authors
Kim, Chan-Sik
Lee, Yun Mi
Kim, Young Sook
Kim, Hyojun
Sohn, Eun Jin
Jeong, Il-Ha
Kim, Jin Sook
Jang, Dae Sik
Kim, Junghyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications, including diabetic nephropathy.
KIOM-79, an 80% ethanolic extract obtained from parched Puerariae Radix, gingered Magnolia Cortex, Glycyrrhiza Radix and Euphorbia Radix, was investigated for its effects on the development of renal disease in Zucker diabetic fatty rats, an animal model of type 2 diabetes.
In vitro inhibitory effect of KIOM-79 on AGEs cross-linking was examined by enzyme-linked immunosorbent assay (ELISA).
KIOM-79 (50 mg/kg/day) was given to Zucker diabetic fatty rats for 13 weeks.
Body and kidney weight, blood glucose, glycated hemoglobin, urinary albumin and creatinine excretions were monitored.
Kidney histopathology, collagen accumulation, fibrinogen and transforming growth factor-beta 1 (TGF-β1) expression were also examined.
KIOM-79 reduced blood glucose, kidney weight, histologic renal damage and albuminuria in Zucker diabetic fatty rats.
KIOM-79 prevented glomerulosclerosis, tubular degeneration, collagen deposition and podocyte apoptosis.
In the renal cortex, TGF-β1, fibronectin mRNA and protein were significantly reduced by KIOM-79 treatment.
KIOM-79 reduces AGEs accumulation in vivo, AGE–protein cross-linking and protein oxidation.
KIOM-79 could be beneficial in preventing the progression of diabetic glomerularsclerosis in type 2 diabetic rats by attenuating AGEs deposition in the glomeruli.
American Psychological Association (APA)
Kim, Young Sook& Kim, Junghyun& Kim, Chan-Sik& Sohn, Eun Jin& Lee, Yun Mi& Jeong, Il-Ha…[et al.]. 2011. KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-496738
Modern Language Association (MLA)
Kim, Young Sook…[et al.]. KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-496738
American Medical Association (AMA)
Kim, Young Sook& Kim, Junghyun& Kim, Chan-Sik& Sohn, Eun Jin& Lee, Yun Mi& Jeong, Il-Ha…[et al.]. KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-496738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496738