CXCR4 in Cancer and Its Regulation by PPARγ
Joint Authors
Richard, Cynthia Lee
Blay, Jonathan
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-02
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Chemokines are peptide mediators involved in normal development, hematopoietic and immune regulation, wound healing, and inflammation.
Among the chemokines is CXCL12, which binds principally to its receptor CXCR4 and regulates leukocyte precursor homing to bone marrow and other sites.
This role of CXCL12/CXCR4 is “commandeered” by cancer cells to facilitate the spread of CXCR4-bearing tumor cells to tissues with high CXCL12 concentrations.
High CXCR4 expression by cancer cells predisposes to aggressive spread and metastasis and ultimately to poor patient outcomes.
As well as being useful as a marker for disease progression, CXCR4 is a potential target for anticancer therapies.
It is possible to interfere directly with the CXCL12:CXCR4 axis using peptide or small-molecular-weight antagonists.
A further opportunity is offered by promoting strategies that downregulate CXCR4 pathways: CXCR4 expression in the tumor microenvironment is modulated by factors such as hypoxia, nucleosides, and eicosanoids.
Another promising approach is through targeting PPAR to suppress CXCR4 expression.
Endogenous PPARγ such as 15-deoxy-Δ12,14-PGJ2 and synthetic agonists such as the thiazolidinediones both cause downregulation of CXCR4 mRNA and receptor.
Adjuvant therapy using PPARγ agonists may, by stimulating PPARγ-dependent downregulation of CXCR4 on cancer cells, slow the rate of metastasis and impact beneficially on disease progression.
American Psychological Association (APA)
Richard, Cynthia Lee& Blay, Jonathan. 2008. CXCR4 in Cancer and Its Regulation by PPARγ. PPAR Research،Vol. 2008, no. 2008, pp.1-19.
https://search.emarefa.net/detail/BIM-497337
Modern Language Association (MLA)
Richard, Cynthia Lee& Blay, Jonathan. CXCR4 in Cancer and Its Regulation by PPARγ. PPAR Research No. 2008 (2008), pp.1-19.
https://search.emarefa.net/detail/BIM-497337
American Medical Association (AMA)
Richard, Cynthia Lee& Blay, Jonathan. CXCR4 in Cancer and Its Regulation by PPARγ. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-19.
https://search.emarefa.net/detail/BIM-497337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497337