Peroxisome Proliferator-Activated Receptor βδ in the Brain : Facts and Hypothesis
Joint Authors
Quignodon, Laure
Desvergne, Bèatrice
Hall, M. G.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-11-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
peroxisome proliferator-activated receptors (PPARs) are nuclear receptors acting as lipid sensors.
Besides its metabolic activity in peripheral organs, the PPAR beta/delta isotype is highly expressed in the brain and its deletion in mice induces a brain developmental defect.
Nevertheless, exploration of PPARβ action in the central nervous system remains sketchy.
The lipid content alteration observed in PPARβ null brains and the positive action of PPARβ agonists on oligodendrocyte differentiation, a process characterized by lipid accumulation, suggest that PPARβ acts on the fatty acids and/or cholesterol metabolisms in the brain.
PPARβ could also regulate central inflammation and antioxidant mechanisms in the damaged brain.
Even if not fully understood, the neuroprotective effect of PPARβ agonists highlights their potential benefit to treat various acute or chronic neurological disorders.
In this perspective, we need to better understand the basic function of PPARβ in the brain.
This review proposes different leads for future researches.
American Psychological Association (APA)
Hall, M. G.& Quignodon, Laure& Desvergne, Bèatrice. 2008. Peroxisome Proliferator-Activated Receptor βδ in the Brain : Facts and Hypothesis. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-497416
Modern Language Association (MLA)
Hall, M. G.…[et al.]. Peroxisome Proliferator-Activated Receptor βδ in the Brain : Facts and Hypothesis. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-497416
American Medical Association (AMA)
Hall, M. G.& Quignodon, Laure& Desvergne, Bèatrice. Peroxisome Proliferator-Activated Receptor βδ in the Brain : Facts and Hypothesis. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-497416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497416