Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial components.
Triggering TLRs results in increased expression of multiple inflammatory genes, which then play a protective role against infection.
However, aberrant activation of TLR signaling has a significant impact on the onset of cancer, allergy, sepsis and autoimmunity.
Various adaptor proteins, including MyD88, IRAKs, TIRAP, TRIF, and TRAM, are involved in specific TLR signaling pathways.
This article reviews the role of these molecules in TLR signaling, and discusses the impact of this pathway on various disease scenarios.
Given their important role in infectious and non-infectious disease settings, TLRs and their signaling pathways emerge as attractive targets for therapeutics.
American Psychological Association (APA)
Zhu, Jiankun& Mohan, Chandra. 2010. Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-497481
Modern Language Association (MLA)
Zhu, Jiankun& Mohan, Chandra. Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-497481
American Medical Association (AMA)
Zhu, Jiankun& Mohan, Chandra. Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-497481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497481