Global Analysis of miRNA Gene Clusters and Gene Families Reveals Dynamic and Coordinated Expression
Joint Authors
Zhao, Yang
Guo, Li
Chen, Feng
Zhang, Hui
Wu, Qian
Yang, Sheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets.
The compositions of miRNA gene clusters and families are not random, and clustered and homologous miRNAs may have close relationships with overlapped miRNA species.
Members in the miRNA group always had various expression levels, and even some showed larger expression divergence.
Despite the dynamic expression as well as individual difference, these miRNAs always indicated consistent or similar deregulation patterns.
The consistent deregulation expression may contribute to dynamic and coordinated interaction between different miRNAs in regulatory network.
Further, we found that those clustered or homologous miRNAs that were also identified as sense and antisense miRNAs showed larger expression divergence.
miRNA gene clusters and families indicated important biological roles, and the specific distribution and expression further enrich and ensure the flexible and robust regulatory network.
American Psychological Association (APA)
Guo, Li& Yang, Sheng& Zhao, Yang& Zhang, Hui& Wu, Qian& Chen, Feng. 2014. Global Analysis of miRNA Gene Clusters and Gene Families Reveals Dynamic and Coordinated Expression. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-497620
Modern Language Association (MLA)
Guo, Li…[et al.]. Global Analysis of miRNA Gene Clusters and Gene Families Reveals Dynamic and Coordinated Expression. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-497620
American Medical Association (AMA)
Guo, Li& Yang, Sheng& Zhao, Yang& Zhang, Hui& Wu, Qian& Chen, Feng. Global Analysis of miRNA Gene Clusters and Gene Families Reveals Dynamic and Coordinated Expression. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-497620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497620