Efficacy of Diosmectite (Smecta)® in the Treatment of Acute Watery Diarrhoea in Adults : A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study
Joint Authors
Khediri, Faouzi
Najjar, Taoufik
Garnier, Philippe
Mathiex-Fortunet, Hélène
Cortot, Antoine
Mrad, Abdennebi Ilhem
Doughi, Hedi
Azzouz, Moussadek
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Although diosmectite has demonstrated efficacy in the treatment of acute watery diarrhoea in children, its efficacy in adults still needs to be assessed.
The objective of this study was therefore to assess the efficacy of diosmectite on the time to recovery in adults with acute diarrhoea.
Methods.
A total of 346 adults with at least three watery stools per day over a period of less than 48 hours were prospectively randomized to diosmectite (6 g tid) or placebo during four days.
The primary endpoint was time to diarrhoea recovery.
Results.
In the intention-to-treat population, median time to recovery was 53.8 hours (range [3.7–167.3]) with diosmectite (n=166) versus 69.0 hours [2.2–165.2] with placebo, (n=163; P=.029), which corresponds to a difference of 15.2 hours.
Diosmectite was well tolerated.
Conclusion.
Diosmectite at 6 g tid was well tolerated and reduced the time to recovery of acute watery diarrhoea episode in a clinically relevant manner.
American Psychological Association (APA)
Khediri, Faouzi& Mrad, Abdennebi Ilhem& Azzouz, Moussadek& Doughi, Hedi& Najjar, Taoufik& Mathiex-Fortunet, Hélène…[et al.]. 2011. Efficacy of Diosmectite (Smecta)® in the Treatment of Acute Watery Diarrhoea in Adults : A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-497702
Modern Language Association (MLA)
Khediri, Faouzi…[et al.]. Efficacy of Diosmectite (Smecta)® in the Treatment of Acute Watery Diarrhoea in Adults : A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study. Gastroenterology Research and Practice No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-497702
American Medical Association (AMA)
Khediri, Faouzi& Mrad, Abdennebi Ilhem& Azzouz, Moussadek& Doughi, Hedi& Najjar, Taoufik& Mathiex-Fortunet, Hélène…[et al.]. Efficacy of Diosmectite (Smecta)® in the Treatment of Acute Watery Diarrhoea in Adults : A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-497702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497702