Apple Procyanidins Suppress Amyloid β-Protein Aggregation
Joint Authors
Shirasawa, Takuji
Shimizu, Takahiko
Tagashira, Motoyuki
Toda, Toshihiko
Sunagawa, Tadahiro
Kanda, Tomomasa
Source
Biochemistry Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Procyanidins (PCs) are major components of the apple polyphenols (APs).
We previously reported that treatment with PC extended the mean lifespan of Caenorhabditis elegans (Sunagawa et al., 2011).
In order to estimate the neuroprotective effects of PC, we investigated the antiaggregative activity of PC on amyloid β-protein (Aβ) aggregation, which is a pathological hallmark of Alzheimer's disease.
We herein report that PC significantly suppressed Aβ42 aggregation and dissociated Aβ42 aggregates in a dose-dependent manner, indicating that PC is a potent suppressor of Aβ aggregation.
Furthermore, PC significantly inhibited Aβ42 neurotoxicity and stimulated proliferation in PC-12 cells.
These results suggested that the PC and AP acted as neuroprotective factors against toxic Aβ aggregates.
American Psychological Association (APA)
Toda, Toshihiko& Sunagawa, Tadahiro& Kanda, Tomomasa& Tagashira, Motoyuki& Shirasawa, Takuji& Shimizu, Takahiko. 2011. Apple Procyanidins Suppress Amyloid β-Protein Aggregation. Biochemistry Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-497846
Modern Language Association (MLA)
Toda, Toshihiko…[et al.]. Apple Procyanidins Suppress Amyloid β-Protein Aggregation. Biochemistry Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-497846
American Medical Association (AMA)
Toda, Toshihiko& Sunagawa, Tadahiro& Kanda, Tomomasa& Tagashira, Motoyuki& Shirasawa, Takuji& Shimizu, Takahiko. Apple Procyanidins Suppress Amyloid β-Protein Aggregation. Biochemistry Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-497846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497846
