![](/images/graphics-bg.png)
Ocular Manifestations of Alzheimer’s Disease in Animal Models
Joint Authors
Parnell, Miles
Abdi, Mohamed
Guo, Li
Cordeiro, M. Francesca
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common form of dementia, and the pathological changes of senile plaques (SPs) and neurofibrillary tangles (NFTs) in AD brains are well described.
Clinically, a diagnosis remains a postmortem one, hampering both accurate and early diagnosis as well as research into potential new treatments.
Visual deficits have long been noted in AD patients, and it is becoming increasingly apparent that histopathological changes already noted in the brain also occur in an extension of the brain; the retina.
Due to the optically transparent nature of the eye, it is possible to image the retina at a cellular level noninvasively and thus potentially allow an earlier diagnosis as well as a way of monitoring progression and treatment effects.
Transgenic animal models expressing amyloid precursor protein (APP) presenilin (PS) and tau mutations have been used successfully to recapitulate the pathological findings of AD in the brain.
This paper will cover the ocular abnormalities that have been detected in these transgenic AD animal models.
American Psychological Association (APA)
Parnell, Miles& Guo, Li& Abdi, Mohamed& Cordeiro, M. Francesca. 2012. Ocular Manifestations of Alzheimer’s Disease in Animal Models. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-498016
Modern Language Association (MLA)
Parnell, Miles…[et al.]. Ocular Manifestations of Alzheimer’s Disease in Animal Models. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-498016
American Medical Association (AMA)
Parnell, Miles& Guo, Li& Abdi, Mohamed& Cordeiro, M. Francesca. Ocular Manifestations of Alzheimer’s Disease in Animal Models. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-498016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498016