Hypertrophy of Ligamentum Flavum in Lumbar Spine Stenosis Is Associated with Increased miR-155 Level
Joint Authors
Chen, Bin
Zhong, Guibin
Chen, Jianwei
Wang, Hantao
Qian, Lie
Liu, Zude
Qiao, Zhiguang
Li, Zhanchun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hypertrophy of ligamentum flavum (LF) contributes to lumbar spinal stenosis (LSS) and is caused mainly by fibrosis.
Recent data indicate that miR-155 plays a crucial role in the pathogenesis of different fibrotic diseases.
This study aimed to test the hypothesis that miR-155 exerts effects on LF thickness by regulating collagen expression.
We found that LF thickness and the expression of collagen I and, collagen III were higher in LF from LSS patients than in LF from lumbar disc herniation (LDH) patients (P<0.01).
The expression of miR-155 was significantly higher in LF from LSS group than in LF from LDH group (P<0.01).
miR-155 level was positively correlated with LF thickness (r=0.958, P<0.01), type I collagen level (r=0.825, P<0.01), and type III collagen level (r=0.827, P<0.01).
miR-155 mimic increased mRNA and protein expression of collagen I and collagen III in fibroblasts isolated from LF, while miR-155 sponge decreased mRNA and protein expression of collagen I and III in fibroblasts.
In conclusions, miR-155 is a fibrosis-associated miRNA and may play important role in the pathogenesis of LF hypertrophy.
American Psychological Association (APA)
Chen, Jianwei& Liu, Zude& Zhong, Guibin& Qian, Lie& Li, Zhanchun& Qiao, Zhiguang…[et al.]. 2014. Hypertrophy of Ligamentum Flavum in Lumbar Spine Stenosis Is Associated with Increased miR-155 Level. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-498022
Modern Language Association (MLA)
Chen, Jianwei…[et al.]. Hypertrophy of Ligamentum Flavum in Lumbar Spine Stenosis Is Associated with Increased miR-155 Level. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-498022
American Medical Association (AMA)
Chen, Jianwei& Liu, Zude& Zhong, Guibin& Qian, Lie& Li, Zhanchun& Qiao, Zhiguang…[et al.]. Hypertrophy of Ligamentum Flavum in Lumbar Spine Stenosis Is Associated with Increased miR-155 Level. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-498022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498022