Emerging Role of PPAR-βδ in Inflammatory Process Associated to Experimental Periodontitis
Joint Authors
Oteri, Giacomo
Briguglio, Francesco
Cuzzocrea, Salvatore
Militi, David
Mazzon, Emanuela
Cordasco, Giancarlo
Di Paola, Rosanna
Paterniti, Irene
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of the present study was to evaluate the contribution of peroxisome proliferator-activated receptor (PPAR-β/δ) in animal model of periodontitis.
Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg).
Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially.
Animals received GW0742 (0.3 mg/kg, 10% DMSO, i.p.
after the ligature placement and daily for eight days).
At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed.
One the eighth day after placement of the ligature, we evaluated (1) NF-κB expression, (2) cytokines expression, (3) iNOS expression, (5) the nitration of tyrosine, (6) apoptosis, and (8) the degree of gingivomucosal tissues injury.
Administration of GW0742 significantly decreased all of the parameters of inflammation as described above.
Taken together, these results demonstrate that GW0742 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage.
American Psychological Association (APA)
Di Paola, Rosanna& Briguglio, Francesco& Paterniti, Irene& Mazzon, Emanuela& Oteri, Giacomo& Militi, David…[et al.]. 2011. Emerging Role of PPAR-βδ in Inflammatory Process Associated to Experimental Periodontitis. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-498076
Modern Language Association (MLA)
Di Paola, Rosanna…[et al.]. Emerging Role of PPAR-βδ in Inflammatory Process Associated to Experimental Periodontitis. Mediators of Inflammation No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-498076
American Medical Association (AMA)
Di Paola, Rosanna& Briguglio, Francesco& Paterniti, Irene& Mazzon, Emanuela& Oteri, Giacomo& Militi, David…[et al.]. Emerging Role of PPAR-βδ in Inflammatory Process Associated to Experimental Periodontitis. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-498076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498076