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Alzheimer’s Disease and HLA-A2 : Linking Neurodegenerative to Immune Processes through an In Silico Approach
Joint Authors
Murillo-Rojas, Juan
Cifuentes, Ricardo A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There is a controversial relationship between HLA-A2 and Alzheimer’s disease (AD).
It has been suggested a modifier effect on the risk that depends on genetic loadings.
Thus, the aims of this study were to evaluate this relationship and to reveal genes associated with both concepts the HLA-A gene and AD.
Consequently, we did first a classical systematic review and a meta-analysis of case-control studies.
Next, by means of an in silico approach, we used experimental knowledge of protein-protein interactions to evaluate the top ranked genes shared by both concepts, previously found through text mining.
The meta-analysis did not show a significant pooled OR (1.11, 95% CI: 0.98 to 1.24 in Caucasians), in spite of the fact that four of the included studies had a significant OR > 1 and none of them a significant OR < 1.
In contrast, the in silico approach retrieved nonrandomly shared genes by both concepts (P = 0.02), which additionally encode truly interacting proteins.
The network of proteins encoded by APP, ICAM-1, ITGB2, ITGAL, SELP, SELL, IL2, IL1B, CD4, and CD8A linked immune to neurodegenerative processes and highlighted the potential roles in AD pathogenesis of endothelial regulation, infectious diseases, specific antigen presentation, and HLA-A2 in maintaining synapses.
American Psychological Association (APA)
Cifuentes, Ricardo A.& Murillo-Rojas, Juan. 2014. Alzheimer’s Disease and HLA-A2 : Linking Neurodegenerative to Immune Processes through an In Silico Approach. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-498372
Modern Language Association (MLA)
Cifuentes, Ricardo A.& Murillo-Rojas, Juan. Alzheimer’s Disease and HLA-A2 : Linking Neurodegenerative to Immune Processes through an In Silico Approach. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-498372
American Medical Association (AMA)
Cifuentes, Ricardo A.& Murillo-Rojas, Juan. Alzheimer’s Disease and HLA-A2 : Linking Neurodegenerative to Immune Processes through an In Silico Approach. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-498372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498372