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Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium
Joint Authors
Yune, Tae Young
Park, Moon Suh
Lee, Jee Youn
Byun, Jae Yong
Yeo, Seung Geun
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-κB, which has key roles in inflammation and apoptosis.
We hypothesized that CYLD may regulate the NF-κB signaling pathway in cholesteatoma.
We conducted immunohistochemistry to examine the expression of CYLD and NF-κB in 16 cases of cholesteatoma and paired cases of retroauricular (RA) skin.
In cholesteatoma epithelium, activated NF-κ B expression was significantly higher than in RA skin, whereas CYLD expression was significantly lower in cholesteatoma epithelium than in RA skin (P<.05).
Furthermore, a significant inverse correlation was detected between CYLD and activated NF-κB expression in cholesteatoma epithelium (r=-0.630).
We found that CYLD reduced and activated increased NF-κB in cholesteatoma epithelium in comparison to RA skin.
The inverse correlation between CYLD and activated NF-κB in cholesteatoma may be involved in cholesteatoma epithelial hyperplasia.
American Psychological Association (APA)
Byun, Jae Yong& Yune, Tae Young& Lee, Jee Youn& Yeo, Seung Geun& Park, Moon Suh. 2010. Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-498846
Modern Language Association (MLA)
Byun, Jae Yong…[et al.]. Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium. Mediators of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-498846
American Medical Association (AMA)
Byun, Jae Yong& Yune, Tae Young& Lee, Jee Youn& Yeo, Seung Geun& Park, Moon Suh. Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-498846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498846