Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets
Joint Authors
Batumalaie, Kalaivani
Kumar, Selva
Qvist, Rajes
Ismail, Ikram Shah Bin
Zaman Safi, Sher
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-03
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The growing number of people with diabetes worldwide suggests that diabetic retinopathy (DR) and diabetic macular edema (DME) will continue to be sight threatening factors.
The pathogenesis of diabetic retinopathy is a widespread cause of visual impairment in the world and a range of hyperglycemia-linked pathways have been implicated in the initiation and progression of this condition.
Despite understanding the polyol pathway flux, activation of protein kinase C (KPC) isoforms, increased hexosamine pathway flux, and increased advanced glycation end-product (AGE) formation, pathogenic mechanisms underlying diabetes induced vision loss are not fully understood.
The purpose of this paper is to review molecular mechanisms that regulate cell survival and apoptosis of retinal cells and discuss new and exciting therapeutic targets with comparison to the old and inefficient preventive strategies.
This review highlights the recent advancements in understanding hyperglycemia-induced biochemical and molecular alterations, systemic metabolic factors, and aberrant activation of signaling cascades that ultimately lead to activation of a number of transcription factors causing functional and structural damage to retinal cells.
It also reviews the established interventions and emerging molecular targets to avert diabetic retinopathy and its associated risk factors.
American Psychological Association (APA)
Zaman Safi, Sher& Qvist, Rajes& Kumar, Selva& Batumalaie, Kalaivani& Ismail, Ikram Shah Bin. 2014. Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets. BioMed Research International،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-499096
Modern Language Association (MLA)
Zaman Safi, Sher…[et al.]. Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets. BioMed Research International No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-499096
American Medical Association (AMA)
Zaman Safi, Sher& Qvist, Rajes& Kumar, Selva& Batumalaie, Kalaivani& Ismail, Ikram Shah Bin. Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-499096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499096