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Fasting Upregulates PPARα Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARα Dependent Manner
Joint Authors
Brandsch, Corinna
König, Bettina
Eder, Klaus
Rosenbaum, Susann
Rauer, Christine
Stangl, Gabriele I.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
PPARα is a lipid-activable transcription factor that mediates the adaptive response to fasting.
Recent data indicate an important role of brain PPARα in physiological functions.
However, it has not yet been shown whether PPARα in brain can be activated in the fasting state.
Here we demonstrate that fasting of rats increased mRNA concentrations of typical PPARα target genes implicated in β-oxidation of fatty acids (acyl-CoA oxidase, carnitine palmitoyltransferase-1, medium chain acyl-CoA dehydrogenase) and ketogenesis (mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase) in pituitary gland and partially also in frontal cortex and diencephalon compared to nonfasted animals.
These data strongly indicate that fasting activates PPARα in brain and pituitary gland.
Furthermore, pituitary prolactin and luteinizing hormone-β mRNA concentrations were increased upon fasting in wild-type mice but not in mice lacking PPARα.
For proopiomelanocortin and thyrotropin-β, genotype-specific differences in pituitary mRNA concentrations were observed.
Thus, PPARα seems to be involved in transcriptional regulation of pituitary hormones.
American Psychological Association (APA)
König, Bettina& Rauer, Christine& Rosenbaum, Susann& Brandsch, Corinna& Eder, Klaus& Stangl, Gabriele I.. 2009. Fasting Upregulates PPARα Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARα Dependent Manner. PPAR Research،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-499139
Modern Language Association (MLA)
König, Bettina…[et al.]. Fasting Upregulates PPARα Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARα Dependent Manner. PPAR Research No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-499139
American Medical Association (AMA)
König, Bettina& Rauer, Christine& Rosenbaum, Susann& Brandsch, Corinna& Eder, Klaus& Stangl, Gabriele I.. Fasting Upregulates PPARα Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARα Dependent Manner. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-499139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499139