Serum Parathyroid Hormone Is a New Potential Risk Factor in Multiple Myeloma
Joint Authors
Kang, Min-Gu
Park, Hye-Ri
Choi, Hyun-Jung
Shin, Jong-Hee
Won, Eun-Jeong
Suh, Soon-Pal
Shin, Myung-Geun
Ryang, Dong-Wook
Choi, Hyun-Woo
Kim, Hye-Ran
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We hypothesized that serum PTH might be associated with various clinicopathological parameters in multiple myeloma (MM).
So we investigated the implications of serum PTH in MM patients and the relationship with other risk factors of MM.
A total of 115 patients who were newly diagnosed with MM were enrolled.
Serum PTH level was 24.7 ± 34.9 (ranged 0.0–284.1) pg/mL.
Serum levels of IgG, IgM, FLC-lambda, albumin, and LDH were in positive correlation with serum PTH.
Compared to non-high PTH (<68.3 pg/mL) group, the hazard ratio (HR) for overall survival was higher for group with high PTH level (≥68.3 pg/mL) (HR, 1.710).
Furthermore, the patient group with high PTH level showed inferior progression-free survival than non-high PTH group (P=0.056).
Interestingly, subgroup analysis showed that serum PTH level at diagnosis was associated with risk factors and clinical outcome in MM patients, especially in complete remission group, transplantation cases, ISS stage II cases, and cases without chromosome abnormality.
In conclusion, this study showed that blood PTH level in MM at diagnosis was associated with risk factors and clinical outcome in MM patients.
American Psychological Association (APA)
Kang, Min-Gu& Won, Eun-Jeong& Choi, Hyun-Woo& Kim, Hye-Ran& Choi, Hyun-Jung& Park, Hye-Ri…[et al.]. 2014. Serum Parathyroid Hormone Is a New Potential Risk Factor in Multiple Myeloma. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-499364
Modern Language Association (MLA)
Kang, Min-Gu…[et al.]. Serum Parathyroid Hormone Is a New Potential Risk Factor in Multiple Myeloma. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-499364
American Medical Association (AMA)
Kang, Min-Gu& Won, Eun-Jeong& Choi, Hyun-Woo& Kim, Hye-Ran& Choi, Hyun-Jung& Park, Hye-Ri…[et al.]. Serum Parathyroid Hormone Is a New Potential Risk Factor in Multiple Myeloma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-499364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499364