Studies of Complex Biological Systems with Applications to Molecular Medicine : The Need to Integrate Transcriptomic and Proteomic Approaches
Joint Authors
de Lange, Pieter
Senese, Rosalba
Lombardi, Assunta
Silvestri, Elena
Moreno, Maria
Cioffi, Federica
Glinni, Daniela
Lanni, Antonia
Goglia, Fernando
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-11
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Omics approaches to the study of complex biological systems with potential applications to molecular medicine are attracting great interest in clinical as well as in basic biological research.
Genomics, transcriptomics and proteomics are characterized by the lack of an a priori definition of scope, and this gives sufficient leeway for investigators (a) to discern all at once a globally altered pattern of gene/protein expression and (b) to examine the complex interactions that regulate entire biological processes.
Two popular platforms in “omics” are DNA microarrays, which measure messenger RNA transcript levels, and proteomic analyses, which identify and quantify proteins.
Because of their intrinsic strengths and weaknesses, no single approach can fully unravel the complexities of fundamental biological events.
However, an appropriate combination of different tools could lead to integrative analyses that would furnish new insights not accessible through one-dimensional datasets.
In this review, we will outline some of the challenges associated with integrative analyses relating to the changes in metabolic pathways that occur in complex pathophysiological conditions (viz.
ageing and altered thyroid state) in relevant metabolically active tissues.
In addition, we discuss several new applications of proteomic analysis to the investigation of mitochondrial activity.
American Psychological Association (APA)
Silvestri, Elena& Lombardi, Assunta& de Lange, Pieter& Glinni, Daniela& Senese, Rosalba& Cioffi, Federica…[et al.]. 2010. Studies of Complex Biological Systems with Applications to Molecular Medicine : The Need to Integrate Transcriptomic and Proteomic Approaches. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-499891
Modern Language Association (MLA)
Silvestri, Elena…[et al.]. Studies of Complex Biological Systems with Applications to Molecular Medicine : The Need to Integrate Transcriptomic and Proteomic Approaches. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-499891
American Medical Association (AMA)
Silvestri, Elena& Lombardi, Assunta& de Lange, Pieter& Glinni, Daniela& Senese, Rosalba& Cioffi, Federica…[et al.]. Studies of Complex Biological Systems with Applications to Molecular Medicine : The Need to Integrate Transcriptomic and Proteomic Approaches. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-499891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499891