Introducing Human APOE into Aβ Transgenic Mouse Models
Joint Authors
Youmans, Katherine L.
Tai, Leon M.
LaDu, Mary Jo
Yu, Chunjiang
Jungbauer, Lisa
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk.
Compared to wild type, apoE−/− mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-independent apoE effects on neurodegeneration.
To determine the effects of apoE on Aβ-induced neuropathology, apoE−/− mice were crossed with Aβ-Tg mice, resulting in a significant delay in plaque deposition.
Surprisingly, crossing human-apoE-Tg mice with apoE−/−/Aβ-Tg mice further delayed plaque deposition, which eventually developed in apoE4/Aβ-Tg mice prior to apoE3/Aβ-Tg.
One approach to address hAPOE-induced temporal delay in Aβ pathology is an additional insult, like head injury.
Another is crossing human-apoE-Tg mice with Aβ-Tg mice that have rapid-onset Aβ pathology.
For example, because 5xFAD mice develop plaques by 2 months, the prediction is that human-apoE/5xFAD-Tg mice develop plaques around 6 months and 12 months before other human-apoE/Aβ-Tg mice.
Thus, tractable models for human-apoE/Aβ-Tg mice continue to evolve.
American Psychological Association (APA)
Tai, Leon M.& Youmans, Katherine L.& Jungbauer, Lisa& Yu, Chunjiang& LaDu, Mary Jo. 2011. Introducing Human APOE into Aβ Transgenic Mouse Models. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499968
Modern Language Association (MLA)
Tai, Leon M.…[et al.]. Introducing Human APOE into Aβ Transgenic Mouse Models. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-499968
American Medical Association (AMA)
Tai, Leon M.& Youmans, Katherine L.& Jungbauer, Lisa& Yu, Chunjiang& LaDu, Mary Jo. Introducing Human APOE into Aβ Transgenic Mouse Models. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499968