Adalimumab (TNFα Inhibitor) Therapy Exacerbates IgA Glomerulonephritis Acute Renal Injury and Induces Lupus Autoantibodies in a Psoriasis Patient
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Adalimumab (Humira) is a tumour necrosis factor α (TNFα) inhibitor that is approved for the treatment of rheumatoid arthritis, psoriasis, psoriatic arthritis, Crohn's disease, ankylosing spondylitis, and juvenile idiopathic arthritis (Sullivan and Preda (2009), Klinkhoff (2004), and Medicare Australia).
Use of TNFα inhibitors is associated with the induction of autoimmunity (systemic lupus erythematosus, vasculitis, and sarcoidosis or sarcoid-like granulomas) (Ramos-Casals et al.
(2010)).
We report a patient with extensive psoriasis presenting with renal failure and seropositive lupus markers without classical lupus nephritis after 18 months treatment with adalimumab.
He has renal biopsy proven IgA nephritis instead.
Renal biopsy is the key diagnostic tool in patients presenting with adalimumab induced nephritis and renal failure.
He made a remarkable recovery after adalimumab cessation and steroid treatment.
To our knowledge, this is a unique case of a psoriasis patient presenting with seropositive lupus markers without classical lupus nephritis renal failure and had renal biopsy proven IgA glomerulonephritis after receiving adalimumab.
American Psychological Association (APA)
Wei, S. S.& Sinniah, R.. 2013. Adalimumab (TNFα Inhibitor) Therapy Exacerbates IgA Glomerulonephritis Acute Renal Injury and Induces Lupus Autoantibodies in a Psoriasis Patient. Case Reports in Nephrology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500056
Modern Language Association (MLA)
Wei, S. S.& Sinniah, R.. Adalimumab (TNFα Inhibitor) Therapy Exacerbates IgA Glomerulonephritis Acute Renal Injury and Induces Lupus Autoantibodies in a Psoriasis Patient. Case Reports in Nephrology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-500056
American Medical Association (AMA)
Wei, S. S.& Sinniah, R.. Adalimumab (TNFα Inhibitor) Therapy Exacerbates IgA Glomerulonephritis Acute Renal Injury and Induces Lupus Autoantibodies in a Psoriasis Patient. Case Reports in Nephrology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-500056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500056