Leaky Vaccines Protect Highly Exposed Recipients at a Lower Rate : Implications for Vaccine Efficacy Estimation and Sieve Analysis
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
“Leaky” vaccines are those for which vaccine-induced protection reduces infection rates on a per-exposure basis, as opposed to “all-or-none” vaccines, which reduce infection rates to zero for some fraction of subjects, independent of the number of exposures.
Leaky vaccines therefore protect subjects with fewer exposures at a higher effective rate than subjects with more exposures.
This simple observation has serious implications for analysis methodologies that rely on the assumption that the vaccine effect is homogeneous across subjects.
We argue and show through examples that this heterogeneous vaccine effect leads to a violation of the proportional hazards assumption, to incomparability of infected cases across treatment groups, and to nonindependence of the distributions of the competing failure processes in a competing risks setting.
We discuss implications for vaccine efficacy estimation, correlates of protection analysis, and mark-specific efficacy analysis (also known as sieve analysis).
American Psychological Association (APA)
Edlefsen, Paul T.. 2014. Leaky Vaccines Protect Highly Exposed Recipients at a Lower Rate : Implications for Vaccine Efficacy Estimation and Sieve Analysis. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-500146
Modern Language Association (MLA)
Edlefsen, Paul T.. Leaky Vaccines Protect Highly Exposed Recipients at a Lower Rate : Implications for Vaccine Efficacy Estimation and Sieve Analysis. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-500146
American Medical Association (AMA)
Edlefsen, Paul T.. Leaky Vaccines Protect Highly Exposed Recipients at a Lower Rate : Implications for Vaccine Efficacy Estimation and Sieve Analysis. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-500146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500146