Barrett’s Esophagus : Emerging Knowledge and Management Strategies
Joint Authors
Bhardwaj, Atul
McGarrity, Thomas J.
Stairs, Douglas B.
Mani, Haresh
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The incidence of esophageal adenocarcinoma (EAC) has increased exponentially in the last 3 decades.
Barrett’s esophagus (BE) is the only known precursor of EAC.
Patients with BE have a greater than 40 folds higher risk of EAC compared with the general population.
Recent years have witnessed a revolution in the clinical and molecular research related to BE.
However, several aspects of this condition remain controversial.
Data regarding the true prevalence of BE have varied widely.
Recent studies have suggested a lower incidence of EAC in nondysplastic BE (NDBE) than previously reported.
There is paucity of prospective data showing a survival benefit of screening or surveillance for BE.
Furthermore, the ever-increasing emphasis on healthcare cost containment has called for reexamination of the screening and surveillance strategies for BE.
There is a need for identification of reliable clinical predictors or molecular biomarkers to risk-stratify patients who might benefit the most from screening or surveillance for BE.
Finally, new therapies have emerged for the management of dysplastic BE.
In this paper, we highlight the key areas of controversy and uncertainty surrounding BE.
The paper discusses, in detail, the current literature about the molecular pathogenesis, biomarkers, histopathological diagnosis, and management strategies for BE.
American Psychological Association (APA)
Bhardwaj, Atul& Stairs, Douglas B.& Mani, Haresh& McGarrity, Thomas J.. 2012. Barrett’s Esophagus : Emerging Knowledge and Management Strategies. Pathology Research International،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-500179
Modern Language Association (MLA)
Bhardwaj, Atul…[et al.]. Barrett’s Esophagus : Emerging Knowledge and Management Strategies. Pathology Research International No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-500179
American Medical Association (AMA)
Bhardwaj, Atul& Stairs, Douglas B.& Mani, Haresh& McGarrity, Thomas J.. Barrett’s Esophagus : Emerging Knowledge and Management Strategies. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-500179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500179