A Complex Interplay between Wntβ-Catenin Signalling and the Cell Cycle in the Adult Liver
Joint Authors
Gougelet, Angélique
Colnot, Sabine
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Canonical Wnt signalling, governed by its effector β-catenin, is known for a long time as playing an important role in development, tissue homeostasis, and cancer.
In the liver, it was unravelled as both an oncogenic pathway involved in a subset of liver cancers and a physiological signalling identified as the “zonation-keeper” of the quiescent liver lobule.
This duality has encouraged to explore the role of canonical Wnt in liver regeneration and liver-cell proliferation mainly using murine genetic models of β-catenin overactivation or inactivation.
These studies definitely integrate Wnt signalling within the hepatic network driving regeneration and proliferation.
We will review here the current knowledge concerning the mitogenic effect of Wnt, to switch on its specific role in the liver, which is quiescent but with a great capacity to regenerate.
The duality of β-catenin signalling, associated both with liver quiescence and liver-cell proliferation, will be brought forward.
American Psychological Association (APA)
Gougelet, Angélique& Colnot, Sabine. 2012. A Complex Interplay between Wntβ-Catenin Signalling and the Cell Cycle in the Adult Liver. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-500374
Modern Language Association (MLA)
Gougelet, Angélique& Colnot, Sabine. A Complex Interplay between Wntβ-Catenin Signalling and the Cell Cycle in the Adult Liver. International Journal of Hepatology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-500374
American Medical Association (AMA)
Gougelet, Angélique& Colnot, Sabine. A Complex Interplay between Wntβ-Catenin Signalling and the Cell Cycle in the Adult Liver. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-500374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500374