Current Understanding of the Role of PPARγ in Gastrointestinal Cancers
Joint Authors
Qiao, Liang
Wong, Benjamin C. Y.
Zou, Bing
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Numerous studies have indicated that PPARγ plays multiple roles such as in inflammation, cell cycle control, cell proliferation, apoptosis, and carcinogenesis, thus PPARγ contributes to the homeostasis.
Many in vitro studies have showed that ligand-induced activation of PPARγ possess antitumor effect in many cancers including CRC.
However, the role of PPARγ in gastrointestinal cancers, especially in colorectal cancer, is rather controversial.
Nevertheless, some recent studies with the positive results on the possible application of PPARγ ligands, such as Bezafibrate or Rosiglitazone in gastrointestinal cancers, have suggested a potential usefulness of PPARγ agonists in cancer prevention and therapy.
In this review, the authors discuss the recent developments in the role of PPARγ in gastrointestinal cancers.
American Psychological Association (APA)
Zou, Bing& Qiao, Liang& Wong, Benjamin C. Y.. 2009. Current Understanding of the Role of PPARγ in Gastrointestinal Cancers. PPAR Research،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-500448
Modern Language Association (MLA)
Zou, Bing…[et al.]. Current Understanding of the Role of PPARγ in Gastrointestinal Cancers. PPAR Research No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-500448
American Medical Association (AMA)
Zou, Bing& Qiao, Liang& Wong, Benjamin C. Y.. Current Understanding of the Role of PPARγ in Gastrointestinal Cancers. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-500448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500448