The Incidence of Various Antiphospholipid Antibodies, Measured by Commercial-Based Laboratory, with Recurrent Spontenous Abortion and the Impact of Their Profiles on Reproductive Outcome with Active Anticoagulant Therapy
Joint Authors
Umehara, Nagayoshi
Tanaka, Tadao
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To investigate the incidence of various antiphospholipid antibodies (aPLs), measured by commercial-based laboratory, with recurrent spontaneous abortion (RSA) patients and the impact of the species, isotype, titer, and number of positive aPLs on reproductive outcome in Japanese.
Method.
In this retrospective cohort study, 263 patients with RSA without possible causes were investigated.
Of 131 patients with one or more positive aPL, 82 pregnant women under anticoagulant therapy were evaluated.
Results.
The incidence of various aPLs was almost consistent with previous report.
Overall, successful pregnancy rate with anticoagulant therapy was 91.4% regardless of aPL profiles.
There was no significant difference in the pregnancy maintenance rate between IgG and IgM groups or single positive and multiple positive groups, but there was a tendency for the rate with aspirin to be lower than with aspirin plus heparin in IgG group.
Conclusion.
aPL profile did not affect the pregnancy maintenance rate when anticoagulant therapy was actively introduced, however in IgG group, we recommend combination therapy with aspirin and heparin.
American Psychological Association (APA)
Umehara, Nagayoshi& Tanaka, Tadao. 2012. The Incidence of Various Antiphospholipid Antibodies, Measured by Commercial-Based Laboratory, with Recurrent Spontenous Abortion and the Impact of Their Profiles on Reproductive Outcome with Active Anticoagulant Therapy. ISRN Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-500657
Modern Language Association (MLA)
Umehara, Nagayoshi& Tanaka, Tadao. The Incidence of Various Antiphospholipid Antibodies, Measured by Commercial-Based Laboratory, with Recurrent Spontenous Abortion and the Impact of Their Profiles on Reproductive Outcome with Active Anticoagulant Therapy. ISRN Obstetrics and Gynecology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-500657
American Medical Association (AMA)
Umehara, Nagayoshi& Tanaka, Tadao. The Incidence of Various Antiphospholipid Antibodies, Measured by Commercial-Based Laboratory, with Recurrent Spontenous Abortion and the Impact of Their Profiles on Reproductive Outcome with Active Anticoagulant Therapy. ISRN Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-500657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500657