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Medical Gases : A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation?
Joint Authors
Chen, Lucinda I.
Lang, John D.
Siriussawakul, Arunotai
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ischemia reperfusion injury (IRI) is an inevitable clinical consequence in organ transplantation.
It can lead to early graft nonfunction and contribute to acute and chronic graft rejection.
Advanced molecular biology has revealed the highly complex nature of this phenomenon and few definitive therapies exist.
This paper reviews factors involved in the pathophysiology of IRI and potential ways to attenuate it.
In recent years, inhaled nitric oxide, carbon monoxide, and hydrogen sulfide have been increasingly explored as plausible novel medical gases that can attenuate IRI via multiple mechanisms, including microvascular vasorelaxation, reduced inflammation, and mitochondrial modulation.
Here, we review recent advances in research utilizing inhaled nitric oxide, carbon monoxide, and hydrogen sulfide in animal and human studies of IRI and postulate on its future applications specific to solid organ transplantation.
American Psychological Association (APA)
Siriussawakul, Arunotai& Chen, Lucinda I.& Lang, John D.. 2012. Medical Gases : A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation?. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-500660
Modern Language Association (MLA)
Siriussawakul, Arunotai…[et al.]. Medical Gases : A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation?. Journal of Transplantation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-500660
American Medical Association (AMA)
Siriussawakul, Arunotai& Chen, Lucinda I.& Lang, John D.. Medical Gases : A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation?. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-500660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500660