Regulation of IκBα Function and NF-κB Signaling : AEBP1 Is a Novel Proinflammatory Mediator in Macrophages
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-12
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
NF-κB comprises a family of transcription factors that are critically involved in various inflammatory processes.
In this paper, the role of NF-κB in inflammation and atherosclerosis and the regulation of the NF-κB signaling pathway are summarized.
The structure, function, and regulation of the NF-κB inhibitors, IκBα and IκBβ, are reviewed.
The regulation of NF-κB activity by glucocorticoid receptor (GR) signaling and IκBα sumoylation is also discussed.
This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF-κB transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF-κB via physical interaction with IκBα and a critical mediator of inflammation.
Finally, we summarize the regulatory roles that recently identified IκBα-interacting proteins play in NF-κB signaling.
Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders.
American Psychological Association (APA)
Majdalawieh, Amin& Ro, Hyo-Sung. 2010. Regulation of IκBα Function and NF-κB Signaling : AEBP1 Is a Novel Proinflammatory Mediator in Macrophages. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-27.
https://search.emarefa.net/detail/BIM-500990
Modern Language Association (MLA)
Majdalawieh, Amin& Ro, Hyo-Sung. Regulation of IκBα Function and NF-κB Signaling : AEBP1 Is a Novel Proinflammatory Mediator in Macrophages. Mediators of Inflammation No. 2010 (2010), pp.1-27.
https://search.emarefa.net/detail/BIM-500990
American Medical Association (AMA)
Majdalawieh, Amin& Ro, Hyo-Sung. Regulation of IκBα Function and NF-κB Signaling : AEBP1 Is a Novel Proinflammatory Mediator in Macrophages. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-27.
https://search.emarefa.net/detail/BIM-500990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500990