White Matter Lesions Are Not Related to β-Amyloid Deposition in an Autopsy-Based Study
Joint Authors
Rutten-Jacobs, Loes C. A.
Dederen, P. Jos
Spliet, Wim G. M.
Kiliaan, Amanda J.
Geurts-van Bon, Lenny
de Leeuw, Frank-Erik
Schepens-Franke, Annelieke N.
Gordinou de Gouberville, Marije C.
Wesseling, Pieter
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Population-based studies have investigated the relation between β-amyloid levels in cerebrospinal fluid or plasma and white matter lesions (WMLs).
However, these circulating levels of β-amyloid in cerebrospinal fluid or plasma may not reliably reflect the actual degree of amyloid present in the brain.
Therefore, we investigated the relation between WMLs and β-amyloid plaques and amyloid angiopathy in brain tissue.
WML on MRI or CT were rated in 28 nondemented patients whose neuroimaging was available prior to death.
β-amyloid in plaques and arterioles were immunohistochemically stained and quantified in postmortem brain necropsies.
WMLs were present in 43% of the total population.
Both cortex and periventricular region showed no differences for β-amyloid deposition in either plaques or blood vessel walls in patients with WMLs compared to those without WMLs.
Thus, our results indicate that there is no relation between the degree of WMLs and β-amyloid deposition in the brain.
American Psychological Association (APA)
Rutten-Jacobs, Loes C. A.& de Leeuw, Frank-Erik& Geurts-van Bon, Lenny& Gordinou de Gouberville, Marije C.& Schepens-Franke, Annelieke N.& Dederen, P. Jos…[et al.]. 2011. White Matter Lesions Are Not Related to β-Amyloid Deposition in an Autopsy-Based Study. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-501265
Modern Language Association (MLA)
Rutten-Jacobs, Loes C. A.…[et al.]. White Matter Lesions Are Not Related to β-Amyloid Deposition in an Autopsy-Based Study. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-501265
American Medical Association (AMA)
Rutten-Jacobs, Loes C. A.& de Leeuw, Frank-Erik& Geurts-van Bon, Lenny& Gordinou de Gouberville, Marije C.& Schepens-Franke, Annelieke N.& Dederen, P. Jos…[et al.]. White Matter Lesions Are Not Related to β-Amyloid Deposition in an Autopsy-Based Study. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-501265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501265