Factors Influencing Risk of Premature Mortality in Community Cases of Depression : A Meta-Analytic Review
Joint Authors
Page, Andrew
Whiteford, Harvey A.
Baxter, Amanda J.
Source
Epidemiology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Depressive disorders are associated with substantial risk of premature mortality.
A number of factors may contribute to reported risk estimates, making it difficult to determine actual risk of excess mortality in community cases of depression.
The aim of this study is to conduct a systematic review and meta-analysis of excess mortality in population-based studies of clinically defined depression.
Methods.
Population-based studies reporting all-cause mortality associated with a clinically defined depressive disorder were included in the systematic review.
Estimates of relative risk for excess mortality in population-representative cases of clinical depressive disorders were extracted.
A meta-analysis was conducted using Stata to pool estimates of excess mortality and identify sources of heterogeneity within the data.
Results.
Twenty-one studies reporting risk of excess mortality in clinical depression were identified.
A significantly higher risk of mortality was found for major depression (RR 1.92 95% CI 1.65–2.23), but no significant difference was found for dysthymia (RR 1.37 95% CI 0.93–2.00).
Relative risk of excess mortality was not significantly different following the adjustment of reported risk estimates.
Conclusion.
A mortality gradient was identified with increasing severity of clinical depression.
Recognition of depressive symptoms in general practice and appropriate referral for evidence-based treatment may help improve outcomes, particularly in patients with comorbid physical disorders.
American Psychological Association (APA)
Baxter, Amanda J.& Page, Andrew& Whiteford, Harvey A.. 2011. Factors Influencing Risk of Premature Mortality in Community Cases of Depression : A Meta-Analytic Review. Epidemiology Research International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-501795
Modern Language Association (MLA)
Baxter, Amanda J.…[et al.]. Factors Influencing Risk of Premature Mortality in Community Cases of Depression : A Meta-Analytic Review. Epidemiology Research International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-501795
American Medical Association (AMA)
Baxter, Amanda J.& Page, Andrew& Whiteford, Harvey A.. Factors Influencing Risk of Premature Mortality in Community Cases of Depression : A Meta-Analytic Review. Epidemiology Research International. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-501795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501795