New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication
Joint Authors
Lubik, Amy A.
Nelson, Colleen C.
Sarkar, Phoebe L.
Gunter, Jennifer H.
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Obesity and type 2 diabetes are recognised risk factors for the development of some cancers and, increasingly, predict more aggressive disease, treatment failure, and cancer-specific mortality.
Many factors may contribute to this clinical observation.
Hyperinsulinaemia, dyslipidaemia, hypoxia, ER stress, and inflammation associated with expanded adipose tissue are thought to be among the main culprits driving malignant growth and cancer advancement.
This observation has led to the proposal of the potential utility of “old players” for the treatment of type 2 diabetes and metabolic syndrome as new cancer adjuvant therapeutics.
Androgen-regulated pathways drive proliferation, differentiation, and survival of benign and malignant prostate tissue.
Androgen deprivation therapy (ADT) exploits this dependence to systemically treat advanced prostate cancer resulting in anticancer response and improvement of cancer symptoms.
However, the initial therapeutic response from ADT eventually progresses to castrate resistant prostate cancer (CRPC) which is currently incurable.
ADT rapidly induces hyperinsulinaemia which is associated with more rapid treatment failure.
We discuss current observations of cancer in the context of obesity, diabetes, and insulin-lowering medication.
We provide an update on current treatments for advanced prostate cancer and discuss whether metabolic dysfunction, developed during ADT, provides a unique therapeutic window for rapid translation of insulin-sensitising medication as combination therapy with antiandrogen targeting agents for the management of advanced prostate cancer.
American Psychological Association (APA)
Gunter, Jennifer H.& Sarkar, Phoebe L.& Lubik, Amy A.& Nelson, Colleen C.. 2013. New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-501861
Modern Language Association (MLA)
Gunter, Jennifer H.…[et al.]. New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication. International Journal of Cell Biology No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-501861
American Medical Association (AMA)
Gunter, Jennifer H.& Sarkar, Phoebe L.& Lubik, Amy A.& Nelson, Colleen C.. New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-501861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501861