Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis
Joint Authors
Rovaris, Marco
Vaghi, M.
Zaffaroni, M.
Meazza, C.
Gironi, M.
Solaro, C.
Albertini, R.
Nemni, R.
Bozzola, Mauro
Montagna, L.
Batocchi, Anna Paola
Source
Multiple Sclerosis International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Evidence suggests that neurohormones such as GH and IGF-I are involved in the neuroreparative processes in multiple sclerosis (MS).
GH and IGF-I blood levels in naïve MS patients with different disease courses were investigated in this study.
Serum GH and IGF-I in untreated MS patients (n=64), healthy controls (HC, n=62), and patients affected by other neurological diseases (OND, n=46) were evaluated with a solid-phase-enzyme-labeled-chemiluminescent-immunometric assay.
No differences were detected in GH across MS, OND, and HC (MS=0.87±1.32 ng/mL; OND=1.66±3.7; and HC=1.69±3.35; P=0.858) when considering gender, disease duration, and disease course.
However, GH was lower (P=0.007) in patients with more severe disease (expanded disability scale score, EDSS≥4.0) compared with milder forms (EDSS<4).
IGF-I l did not differ across the 3 groups (P=0.160), as far as concern disease course, disability, and gender were.
Lower IGF-I levels were detected in subjects older than 50 years compared to younger ones for all 3 groups.
Lower GH was detected in patients with more severe MS, and age was confirmed as the main factor driving IGF-I levels in all subjects.
These findings, relying on the natural course of the disease, could help in shedding lights on the mechanisms involved in autoreparative failure associated with poorer prognosis in MS.
American Psychological Association (APA)
Gironi, M.& Solaro, C.& Meazza, C.& Vaghi, M.& Montagna, L.& Rovaris, Marco…[et al.]. 2013. Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis. Multiple Sclerosis International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-502025
Modern Language Association (MLA)
Gironi, M.…[et al.]. Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis. Multiple Sclerosis International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-502025
American Medical Association (AMA)
Gironi, M.& Solaro, C.& Meazza, C.& Vaghi, M.& Montagna, L.& Rovaris, Marco…[et al.]. Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis. Multiple Sclerosis International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-502025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502025