Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyond β-Amyloid : Insights from Clinical Trials
Joint Authors
Deng, Yulin
Jia, Qiutian
Qing, Hong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles.
It is one of the most alarming illnesses to elderly people.
No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have been intensively investigated.
Outcomes of clinical trials suggested several pitfalls in the choice of biomarkers, development of drug candidates, and interaction of drug-targeted molecules; however, they also aroused concerns on the potential deficiency in our understanding of pathogenesis of AD, and ultimately stimulated the advent of novel drug targets tests.
The anticipated increase of AD patients in next few decades makes development of better therapy an urgent issue.
Here we attempt to summarize and compare putative therapeutic strategies that have completed clinical trials or are currently being tested from various perspectives to provide insights for treatments of Alzheimer’s disease.
American Psychological Association (APA)
Jia, Qiutian& Deng, Yulin& Qing, Hong. 2014. Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyond β-Amyloid : Insights from Clinical Trials. BioMed Research International،Vol. 2014, no. 2014, pp.1-22.
https://search.emarefa.net/detail/BIM-502076
Modern Language Association (MLA)
Jia, Qiutian…[et al.]. Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyond β-Amyloid : Insights from Clinical Trials. BioMed Research International No. 2014 (2014), pp.1-22.
https://search.emarefa.net/detail/BIM-502076
American Medical Association (AMA)
Jia, Qiutian& Deng, Yulin& Qing, Hong. Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyond β-Amyloid : Insights from Clinical Trials. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-22.
https://search.emarefa.net/detail/BIM-502076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502076