Gastrointestinal and Hepatotoxicity Assessment of an Anticancer Extract from Muricid Molluscs
Joint Authors
McIver, Cassandra M.
Le Leu, Richard K.
Abbott, Catherine A.
Westley, Chantel B.
Benkendorff, Kirsten
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Marine molluscs from the family Muricidae are under development as a potential medicinal food for the prevention of colon cancer and treatment of gynaecological cancers.
Here we report the outcome of the first in vivo toxicity assessment on an anticancer extract from a muricid mollusc containing brominated indole derivatives.
Mice received the concentrated lipophilic extract by daily oral gavage over a two-week period.
Mortality or clinical toxicity symptoms resulting from the extract were not detected during the trial, and there was no difference in the body weight of treated and control mice at the end of the trial.
Histological analysis revealed some evidence for mild, idiosyncratic effects on the gastrointestinal tract and liver, including necrosis, fatty change, and inflammation in a small proportion (<40%) of mice.
This is likely to result from first-pass hepatic metabolism of tyrindoxyl sulphate combined with second-pass metabolism of indoles.
Overall however, oral administration of muricid extract containing brominated indoles does not result in severe clinical toxicity.
American Psychological Association (APA)
Westley, Chantel B.& Benkendorff, Kirsten& McIver, Cassandra M.& Le Leu, Richard K.& Abbott, Catherine A.. 2013. Gastrointestinal and Hepatotoxicity Assessment of an Anticancer Extract from Muricid Molluscs. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-502103
Modern Language Association (MLA)
Westley, Chantel B.…[et al.]. Gastrointestinal and Hepatotoxicity Assessment of an Anticancer Extract from Muricid Molluscs. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-502103
American Medical Association (AMA)
Westley, Chantel B.& Benkendorff, Kirsten& McIver, Cassandra M.& Le Leu, Richard K.& Abbott, Catherine A.. Gastrointestinal and Hepatotoxicity Assessment of an Anticancer Extract from Muricid Molluscs. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-502103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502103