Hypoxia in Diabetic Kidneys
Joint Authors
Haneda, Masakazu
Takiyama, Yumi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is now a leading cause of end-stage renal disease.
In addition, DN accounts for the increased mortality in type 1 and type 2 diabetes, and then patients without DN achieve long-term survival compatible with general population.
Hypoxia represents an early event in the development and progression of DN, and hypoxia-inducible factor- (HIF-) 1 mediates the metabolic responses to renal hypoxia.
Diabetes induces the “fraternal twins” of hypoxia, that is, pseudohypoxia and hypoxia.
The kidneys are susceptible to hyperoxia because they accept 20% of the cardiac output.
Therefore, the kidneys have specific vasculature to avoid hyperoxia, that is, AV oxygen shunting.
The NAD-dependent histone deacetylases (HDACs) sirtuins are seven mammalian proteins, SIRTs 1–7, which are known to modulate longevity and metabolism.
Recent studies demonstrated that some isoforms of sirtuins inhibit the activation of HIF by deacetylation or noncatalyzing effects.
The kidneys, which have a vascular system that protects them against hyperoxia, unfortunately experience extraordinary hypernutrition today.
Then, an unexpected overload of glucose augments the oxygen consumption, which ironically results in hypoxia.
This review highlights the primary role of HIF in diabetic kidneys for the metabolic adaptation to diabetes-induced hypoxia.
American Psychological Association (APA)
Takiyama, Yumi& Haneda, Masakazu. 2014. Hypoxia in Diabetic Kidneys. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-502115
Modern Language Association (MLA)
Takiyama, Yumi& Haneda, Masakazu. Hypoxia in Diabetic Kidneys. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-502115
American Medical Association (AMA)
Takiyama, Yumi& Haneda, Masakazu. Hypoxia in Diabetic Kidneys. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-502115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502115