The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia
Joint Authors
Régis, Bordet
Marche, Kevin
Rolland, Benjamin
Cottencin, Olivier
Source
Schizophrenia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Oxidative stress has been implicated in neurodevelopmental theories of schizophrenia.
Antioxidant Peroxysome Proliferator-Activated Receptors α (PPARα) agonist fenofibrate has neuroprotective properties and could reverse early preclinical infringements that could trigger the illness.
We have evaluated the neuroprotective interest of fenofibrate in a neurodevelopmental rat model of schizophrenia.
The oxidative lesion induced by Kainic Acid (KA) injection at postnatal day (PND) 7 has previously been reported to disrupt Prepulse Inhibition (PPI) at PND56 but not at PND35.
In 4 groups of 15 male rats each, KN (KA-PND7 + normal postweaning food), KF (KA-PND7 + fenofibrate 0.2% food), ON (saline-PND7 + normal food), and OF (saline + fenofibrate food), PPI was recorded at PND35 and PND56.
Three levels of prepulse were used: 73 dB, 76 dB, and 82 dB for a pulse at 120 dB.
Four PPI scores were analyzed: PPI73, PPI76, PPI82, and mean PPI (PPIm).
Two-way ANOVAs were used to evaluate the effects of both factors (KA + fenofibrate), and, in case of significant results, intergroup Student’s t-tests were performed.
We notably found a significant difference (P<0.05) in PPIm between groups KN and KF at PND56, which supposes that fenofibrate could be worthy of interest for early neuroprotection in schizophrenia.
American Psychological Association (APA)
Rolland, Benjamin& Marche, Kevin& Cottencin, Olivier& Régis, Bordet. 2012. The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia. Schizophrenia Research and Treatment،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-502348
Modern Language Association (MLA)
Rolland, Benjamin…[et al.]. The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia. Schizophrenia Research and Treatment No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-502348
American Medical Association (AMA)
Rolland, Benjamin& Marche, Kevin& Cottencin, Olivier& Régis, Bordet. The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia. Schizophrenia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-502348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502348