Clinic-Based Retrospective Analysis of Psychopharmacology for Behavior in Fragile X Syndrome
Joint Authors
Hervey, Crystal
Berry-Kravis, Elizabeth
Mathur, Shaguna
Sumis, Allison
Source
International Journal of Pediatrics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fragile X syndrome (FXS) is associated with behavior that limits functioning, including distractibility, hyperactivity, impulsivity, hyperarousal, anxiety, mood dysregulation, and aggression.
Medication response and side effect data were reviewed retrospectively for 257 patients (age 14±11 years, range 4–60 years, 203 M, 54 F) attending an FXS clinic.
Treatment success rates were defined as the percentage of positive response in the form of documented clinical report of improvement in the behavior(s) being targeted over at least a 6-month period on the medication, without side effects requiring medication discontinuance, while failures were defined as discontinuance of medication due to lack of clinical effectiveness or side effects.
Success rate for treatment of targeted behaviors with trials of individual medications was 55% for stimulants, 53% for antidepressants, 62% for alpha2-agonists, and 54% for antipsychotics.
With sequential trials of different medications in the same class, success rate improved to 73–77%.
Side effect-related failures were highest for antipsychotics.
Systematic psychopharmacologic intervention targeted to behavioral symptoms appears helpful in the majority of patients with FXS.
American Psychological Association (APA)
Berry-Kravis, Elizabeth& Sumis, Allison& Hervey, Crystal& Mathur, Shaguna. 2012. Clinic-Based Retrospective Analysis of Psychopharmacology for Behavior in Fragile X Syndrome. International Journal of Pediatrics،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-502671
Modern Language Association (MLA)
Berry-Kravis, Elizabeth…[et al.]. Clinic-Based Retrospective Analysis of Psychopharmacology for Behavior in Fragile X Syndrome. International Journal of Pediatrics No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-502671
American Medical Association (AMA)
Berry-Kravis, Elizabeth& Sumis, Allison& Hervey, Crystal& Mathur, Shaguna. Clinic-Based Retrospective Analysis of Psychopharmacology for Behavior in Fragile X Syndrome. International Journal of Pediatrics. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-502671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502671