Expression of Tra2β in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis
Joint Authors
Tyson-Capper, Alison
Ehrmann, Ingrid
Best, Andrew
Elliott, David J.
Dagliesh, Caroline
Kheirollahi-Kouhestani, Mahsa
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The splicing regulator proteins SRSF1 (also known as ASF/SF2) and SRSF3 (also known as SRP20) belong to the SR family of proteins and can be upregulated in cancer.
The SRSF1 gene itself is amplified in some cancer cells, and cancer-associated changes in the expression of MYC also increase SRSF1 gene expression.
Increased concentrations of SRSF1 protein promote prooncogenic splicing patterns of a number of key regulators of cell growth.
Here, we review the evidence that upregulation of the SR-related Tra2β protein might have a similar role in cancer cells.
The TRA2B gene encoding Tra2β is amplified in particular tumours including those of the lung, ovary, cervix, stomach, head, and neck.
Both TRA2B RNA and Tra2β protein levels are upregulated in breast, cervical, ovarian, and colon cancer, and Tra2β expression is associated with cancer cell survival.
The TRA2B gene is a transcriptional target of the protooncogene ETS-1 which might cause higher levels of expression in some cancer cells which express this transcription factor.
Known Tra2β splicing targets have important roles in cancer cells, where they affect metastasis, proliferation, and cell survival.
Tra2β protein is also known to interact directly with the RBMY protein which is implicated in liver cancer.
American Psychological Association (APA)
Best, Andrew& Dagliesh, Caroline& Ehrmann, Ingrid& Kheirollahi-Kouhestani, Mahsa& Tyson-Capper, Alison& Elliott, David J.. 2013. Expression of Tra2β in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-502744
Modern Language Association (MLA)
Best, Andrew…[et al.]. Expression of Tra2β in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis. International Journal of Cell Biology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-502744
American Medical Association (AMA)
Best, Andrew& Dagliesh, Caroline& Ehrmann, Ingrid& Kheirollahi-Kouhestani, Mahsa& Tyson-Capper, Alison& Elliott, David J.. Expression of Tra2β in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-502744
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502744