Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes
Joint Authors
Soulières, Denis
Tabet, Jean-Claude
Weng, Xiaoduan
Bissada, Eric
Abou Chacra, Zahi
Guertin, Louis
Thibaudeau, Ève
Audet, Marie-Lise
Fortin, Bernard
Abboud, O.
Lambert, Louise
Nguyen-Tan, Phuc Félix
Source
International Journal of Otolaryngology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
RAS gene mutations have an impact on treatment response and overall prognosis for certain types of cancer.
Objectives.
To determine the prevalence and impact of K-RAS codons 12 and 13 mutations in patients with locally advanced HNSCC treated with primary or adjuvant chemo-radiation.
Methods.
428 consecutive patients were treated with chemo-radiation therapy and followed for a median of 37 months.
From these, 199 paraffin embedded biopsy or surgical specimens were retrieved.
DNA was isolated and analyzed for K-RAS mutational status.
Results.
DNA extraction was successful in 197 samples.
Of the 197 specimens, 3.5% presented K-RAS codon 12 mutations.
For mutated cases and non-mutated cases, complete initial response to chemoradiation therapy was 71 and 73% (P=0.32).
LRC was respectively 32 and 83% (P=0.03), DFS was 27 and 68% (P=0.12), distant metastasis-free survival was 100 and 81% (P=0.30) and OS was 57 and 65% (P=0.14) at three years.
K-Ras codon 13 analysis revealed no mutation.
Conclusion.
K-RAS codon 12 mutational status, although not associated with a difference in response rate, may influence the failure pattern and the type of therapy offered to patients with HNSCC.
Our study did not reveal any mutation of K-RAS codon 13.
American Psychological Association (APA)
Bissada, Eric& Abboud, O.& Abou Chacra, Zahi& Guertin, Louis& Weng, Xiaoduan& Nguyen-Tan, Phuc Félix…[et al.]. 2013. Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes. International Journal of Otolaryngology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-503010
Modern Language Association (MLA)
Bissada, Eric…[et al.]. Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes. International Journal of Otolaryngology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-503010
American Medical Association (AMA)
Bissada, Eric& Abboud, O.& Abou Chacra, Zahi& Guertin, Louis& Weng, Xiaoduan& Nguyen-Tan, Phuc Félix…[et al.]. Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes. International Journal of Otolaryngology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-503010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503010