Androgen Receptor Signalling in Prostate Cancer : The Functional Consequences of Acetylation
Joint Authors
Lavery, Derek N.
Bevan, Charlotte L.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The androgen receptor (AR) is a ligand activated transcription factor and member of the steroid hormone receptor (SHR) subfamily of nuclear receptors.
In the early stages of prostate carcinogenesis, tumour growth is dependent on androgens, and AR directly mediates these effects by modulating gene expression.
During transcriptional regulation, the AR recruits numerous cofactors with acetylation-modifying enzymatic activity, the best studied include p300/CBP and the p160/SRC family of coactivators.
It is known that recruitment of histone acetyltransferases (HATs) and histone deacetylases (HDACs) is key in fine-tuning responses to androgens and is thus likely to play a role in prostate cancer progression.
Further, these proteins can also modify the AR itself.
The functional consequences of AR acetylation, the role of modifying enzymes in relation to AR transcriptional response, and prostate cancer will be discussed.
American Psychological Association (APA)
Lavery, Derek N.& Bevan, Charlotte L.. 2010. Androgen Receptor Signalling in Prostate Cancer : The Functional Consequences of Acetylation. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-504254
Modern Language Association (MLA)
Lavery, Derek N.& Bevan, Charlotte L.. Androgen Receptor Signalling in Prostate Cancer : The Functional Consequences of Acetylation. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-504254
American Medical Association (AMA)
Lavery, Derek N.& Bevan, Charlotte L.. Androgen Receptor Signalling in Prostate Cancer : The Functional Consequences of Acetylation. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-504254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504254