Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids
Joint Authors
Licciardi, Paul V.
Ververis, Katherine
Karagiannis, Tom C.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Changes in diet can also have dramatic effects on the composition of gut microbiota.
Commensal bacteria of the gastrointestinal tract are critical regulators of health and disease by protecting against pathogen encounter whilst also maintaining immune tolerance to certain allergens.
Moreover, consumption of fibre and vegetables typical of a non-Western diet generates substantial quantities of short-chain fatty acids (SCFAs) which have potent anti-inflammatory properties.
Dietary interventions such as probiotic supplementation have been investigated for their pleiotropic effects on microbiota composition and immune function.
Probiotics may restore intestinal dysbiosis and improve clinical disease through elevated SCFA levels in the intestine.
Although the precise mechanisms by which such dietary factors mediate these effects, SCFA metabolites such as butyrate also function as histone deacetylase inhibitors (HDACi), that can act on the epigenome through chromatin remodeling changes.
The aim of this review is to provide an overview of HDAC enzymes and to discuss the biological effects of HDACi.
Further, we discuss the important relationship between diet and the balance between health and disease and how novel dietary interventions such as probiotics could be alternative approach for the prevention and/or treatment of chronic inflammatory disease through modulation of the intestinal microbiome.
American Psychological Association (APA)
Licciardi, Paul V.& Ververis, Katherine& Karagiannis, Tom C.. 2011. Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids. ISRN Allergy،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504860
Modern Language Association (MLA)
Licciardi, Paul V.…[et al.]. Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids. ISRN Allergy No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-504860
American Medical Association (AMA)
Licciardi, Paul V.& Ververis, Katherine& Karagiannis, Tom C.. Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids. ISRN Allergy. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504860