Anti-Inflammatory Dimethylfumarate : A Potential New Therapy for Asthma?
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Asthma is a chronic inflammatory disease of the airways, which results from the deregulated interaction of inflammatory cells and tissue forming cells.
Beside the derangement of the epithelial cell layer, the most prominent tissue pathology of the asthmatic lung is the hypertrophy and hyperplasia of the airway smooth muscle cell (ASMC) bundles, which actively contributes to airway inflammation and remodeling.
ASMCs of asthma patients secrete proinflammatory chemokines CXCL10, CCL11, and RANTES which attract immune cells into the airways and may thereby initiate inflammation.
None of the available asthma drugs cures the disease—only symptoms are controlled.
Dimethylfumarate (DMF) is used as an anti-inflammatory drug in psoriasis and showed promising results in phase III clinical studies in multiple sclerosis patients.
In regard to asthma therapy, DMF has been anecdotally reported to reduce asthma symptoms in patients with psoriasis and asthma.
Here we discuss the potential use of DMF as a novel therapy in asthma on the basis of in vitro studies of its inhibitory effect on ASMC proliferation and cytokine secretion in ASMCs.
American Psychological Association (APA)
Seidel, Petra& Roth, Michael. 2013. Anti-Inflammatory Dimethylfumarate : A Potential New Therapy for Asthma?. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-505390
Modern Language Association (MLA)
Seidel, Petra& Roth, Michael. Anti-Inflammatory Dimethylfumarate : A Potential New Therapy for Asthma?. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-505390
American Medical Association (AMA)
Seidel, Petra& Roth, Michael. Anti-Inflammatory Dimethylfumarate : A Potential New Therapy for Asthma?. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-505390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505390