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Therapeutic Implications of PPARγ in Cardiovascular Diseases
Joint Authors
Takano, Hiroyuki
Komuro, Issei
Hasegawa, Hiroshi
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor-γ (PPARγ) is the members of the nuclear receptor superfamily as a master transcriptional factor that promotes differentiation of preadipocytes by activating adipose-specific gene expression.
Although PPARγ is expressed predominantly in adipose tissue and associated with adipocyte differentiation and glucose homeostasis, PPARγ is also present in a variety of cell types including vascular cells and cardiomyocytes.
Activation of PPARγ suppresses production of inflammatory cytokines, and there is accumulating data that PPARγ ligands exert antihypertrophy of cardiomyocytes and anti-inflammatory, antioxidative, and antiproliferative effects on vascular wall cells and cardiomyocytes.
In addition, activation of PPARγ is implicated in the regulation of endothelial function, proliferation and migration of vascular smooth muscle cells, and activation of macrophages.
Many studies suggest that PPARγ ligands not only ameliorate insulin sensitivity, but also have pleiotropic effects on the pathophysiology of atherosclerosis, cardiac hypertrophy, ischemic heart, and myocarditis.
American Psychological Association (APA)
Hasegawa, Hiroshi& Takano, Hiroyuki& Komuro, Issei. 2010. Therapeutic Implications of PPARγ in Cardiovascular Diseases. PPAR Research،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-505450
Modern Language Association (MLA)
Hasegawa, Hiroshi…[et al.]. Therapeutic Implications of PPARγ in Cardiovascular Diseases. PPAR Research No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-505450
American Medical Association (AMA)
Hasegawa, Hiroshi& Takano, Hiroyuki& Komuro, Issei. Therapeutic Implications of PPARγ in Cardiovascular Diseases. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-505450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505450