Application of Proteomics to Soft Tissue Sarcomas
Joint Authors
Kondo, Tadashi
Kubota, Daisuke
Kawai, Akira
Source
International Journal of Proteomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Soft tissue sarcomas are rare and account for less than 1% of all malignant cancers.
Other than development of intensive therapies, the clinical outcome of patients with soft tissue sarcoma remains very poor, particularly when diagnosed at a late stage.
Unique mutations have been associated with certain soft tissue sarcomas, but their etiologies remain unknown.
The proteome is a functional translation of a genome, which directly regulates the malignant features of tumors.
Thus, proteomics is a promising approach for investigating soft tissue sarcomas.
Various proteomic approaches and clinical materials have been used to address clinical and biological issues, including biomarker development, molecular target identification, and study of disease mechanisms.
Several cancer-associated proteins have been identified using conventional technologies such as 2D-PAGE, mass spectrometry, and array technology.
The functional backgrounds of proteins identified were assessed extensively using in vitro experiments, thus supporting expression analysis.
These observations demonstrate the applicability of proteomics to soft tissue sarcoma studies.
However, the sample size in each study was insufficient to allow conclusive results.
Given the low frequency of soft tissue sarcomas, multi-institutional collaborations are required to validate the results of proteomic approaches.
American Psychological Association (APA)
Kondo, Tadashi& Kubota, Daisuke& Kawai, Akira. 2012. Application of Proteomics to Soft Tissue Sarcomas. International Journal of Proteomics،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-505492
Modern Language Association (MLA)
Kondo, Tadashi…[et al.]. Application of Proteomics to Soft Tissue Sarcomas. International Journal of Proteomics No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-505492
American Medical Association (AMA)
Kondo, Tadashi& Kubota, Daisuke& Kawai, Akira. Application of Proteomics to Soft Tissue Sarcomas. International Journal of Proteomics. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-505492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505492