Epidemiological and Clinical Features of Hepatitis B Virus Genotypes among Immigrants in Southern Italy
Joint Authors
Martinelli, Domenico
Di Tullio, Rocco
Scotto, Gaetano
Fazio, Vincenzina
Source
Hepatitis Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background/aims.
This study aims to determine the distribution and clinical features of HBV-genotypes in a population of immigrants affected by HBV-infection.
Methods.
Between 01/2003 and 03/2009, 1623 immigrants were tested for HBV-infection.
Biochemical and virological activities were determined in HBsAg-positive patients; HBV-genotypes were determined, by the INNO-LiPA HBV Genotyping, in the subjects with HBV DNA detectable.
In every patient we evaluated the stage and classified the infection as inactive carrier, mild or moderate/severe chronic hepatitis, cirrhosis, and/or HCC.
Results.
Among the tested subjects, 191 (11.7%) resulted HBsAg-positive, and in 144/191 (75.4%) serum HBV-DNA was detectable.
The genotype distribution was as follows: 45,13% genotype E, 18,1% genotype D, 15,3% genotype B, 13,2% genotype C, 4,9% genotype A, 3,5% mixed genotypes (A–D).
The evaluation of liver disease degree showed that 24.6% patients were inactive carriers of HBV infection, 19.4% presented a immunotolerance phase, 34.5% had mild chronic hepatitis, 13.6% had a moderate/severe chronic hepatitis, 6.3% had cirrhosis, and 1.6% presented HCC.
Conclusions.
Our study evidences a high prevalence of HBV-infection in immigrants, and the potentiality of migratory flow in the introduction of genotype non-D hepatitis B virus.
The Hepatitis B virus genotypes presented significant differences in epidemiological and clinical characteristics.
American Psychological Association (APA)
Scotto, Gaetano& Martinelli, Domenico& Di Tullio, Rocco& Fazio, Vincenzina. 2010. Epidemiological and Clinical Features of Hepatitis B Virus Genotypes among Immigrants in Southern Italy. Hepatitis Research and Treatment،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-505568
Modern Language Association (MLA)
Scotto, Gaetano…[et al.]. Epidemiological and Clinical Features of Hepatitis B Virus Genotypes among Immigrants in Southern Italy. Hepatitis Research and Treatment No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-505568
American Medical Association (AMA)
Scotto, Gaetano& Martinelli, Domenico& Di Tullio, Rocco& Fazio, Vincenzina. Epidemiological and Clinical Features of Hepatitis B Virus Genotypes among Immigrants in Southern Italy. Hepatitis Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-505568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505568