The Multifaceted Granulosa Cell Tumours—Myths and Realities : A Review
Joint Authors
Senger, Jenna-Lynn
Kanthan, Rani
Kanthan, Selliah Chandra
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Granulosa cell tumors (GCTs), representing ~2% of ovarian tumours, are poorly understood neoplasms with unpredictable and undetermined biological behaviour.
Design.
5 unusual presentations of GCT and a retrospective 14-year (1997–2011) surgical pathology review based on patient sex, age, tumour type and concurrent pathology findings are presented to discuss the “myths and realities” of GCTs in the context of relevant evidence-based literature.
Results.
The 5 index cases included (1) a 5 month-old boy with a left testicular mass, (2) a 7-day-old neonate with a large complex cystic mass in the abdomen, (3) a 76-year-old woman with an umbilical mass, (4) a 64-year-old woman with a complex solid-cystic pelvic mass, and (5) a 45 year-old woman with an acute abdomen.
Pathological analysis confirmed the final diagnosis as (1) juvenile GCT, (2) macrofollicular GCT, (3) recurrent GCT 32 years later, (4) collision tumour: colonic adenocarcinoma and GCT, and (5) ruptured GCT.
Conclusion.
GCT is best considered as an unusual indolent neoplasm of low malignant potential with late recurrences that can arise in the ovaries and testicles in both the young and the old.
Multifaceted clinical presentations coupled with the unpredictable biological behaviour with late relapses are diagnostic pitfalls necessitating a high degree of suspicion for accurate clinical and pathological diagnosis.
American Psychological Association (APA)
Kanthan, Rani& Senger, Jenna-Lynn& Kanthan, Selliah Chandra. 2012. The Multifaceted Granulosa Cell Tumours—Myths and Realities : A Review. ISRN Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-505584
Modern Language Association (MLA)
Kanthan, Rani…[et al.]. The Multifaceted Granulosa Cell Tumours—Myths and Realities : A Review. ISRN Obstetrics and Gynecology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-505584
American Medical Association (AMA)
Kanthan, Rani& Senger, Jenna-Lynn& Kanthan, Selliah Chandra. The Multifaceted Granulosa Cell Tumours—Myths and Realities : A Review. ISRN Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-505584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505584